https://pubs.acs.org/toc/aamick/17/28

Journal cover / Applied materials and interfaces: July 16, 2025 Volume 17, Issue 28

Abstract

This study introduces a sophisticated bioelectronic cell chip platform that combines polydimethylsiloxane (PDMS) microwells with indium tin oxide (ITO) electrodes and polydopamine (PDA)-functionalized PDMS/ITO. This integration enhances the sensitivity for real-time monitoring of the proliferation of 3D breast cancer spheroids over extended periods. The distinctive nanocomposite of graphene quantum dots (GQDs), modified to improve membrane penetration, facilitates drug delivery. Cryptotanshinone-conjugated GQDs are utilized to develop a novel anticancer nanocomposite that augments anticancer activities, allowing impedance-based assessment of cancer inhibition in tumor-mimicking spheroids for anticancer drug screening.