Journal cover / Small / Volume 22, Issue 40

https://onlinelibrary.wiley.com/toc/16136829/2026/22/40

Abstract

Clinical Disease Diagnosis

Extracellular vesicle (EV)-associated microRNAs are promising biomarkers for disease diagnosis, but conventional analysis requires laborious EV isolation and RNA extraction. Here, a mix-and-read assay enables the direct quantification of EV-associated microRNAs from unprocessed plasma within 10 minutes through sonication-enhanced liposome–EV fusion. In Research Article e74300, Junyeop Lee, Seonki Hong, and co-workers offer a practical route toward point-of-care molecular testing.